Activation of Ftz-F1-Responsive Genes through Ftz/Ftz-F1 Dependent Enhancers
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چکیده
منابع مشابه
Activation of Ftz-F1-Responsive Genes through Ftz/Ftz-F1 Dependent Enhancers
The orphan nuclear receptor Ftz-F1 is expressed in all somatic nuclei in Drosophila embryos, but mutations result in a pair-rule phenotype. This was explained by the interaction of Ftz-F1 with the homeodomain protein Ftz that is expressed in stripes in the primordia of segments missing in either ftz-f1 or ftz mutants. Ftz-F1 and Ftz were shown to physically interact and coordinately activate th...
متن کاملIdentifying Targets of FTZ and FTZ-F1
Homeobox (Hox) proteins regulate cell fate and segmental identity throughout the animal kingdom. Yet, given the homeodomain's promiscuous DNA binding activity in vitro, it is unclear how they select downstream target genes. The product of fushi tarzu (ftz) is a Hox protein responsible for the development of alternate parasegments within the Drosophila embryo. It has been shown that FTZ interact...
متن کاملZebrafish sex determination and differentiation: Involvement of FTZ-F1 genes
Sex determination is the process deciding the sex of a developing embryo. This is usually determined genetically; however it is a delicate process, which in many cases can be influenced by environmental factors. The mechanisms controlling zebrafish sex determination and differentiation are not known. To date no sex linked genes have been identified in zebrafish and no sex chromosomes have been ...
متن کاملFtz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene.
The fushi tarazu pair-rule gene is required for the formation of alternating parasegmental boundaries in the Drosophila embryo. fushi tarazu encodes a homeodomain protein necessary for transcription of the engrailed gene in even-numbered parasegments. Here we report that, within an engrailed enhancer, adjacent and conserved binding sites for the Fushi tarazu protein and a cofactor are each nece...
متن کاملThe nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains
The Drosophila homeodomain protein Fushi Tarazu (Ftz) and its partner, the orphan receptor Ftz-F1, are members of two distinct families of DNA binding transcriptional regulators. Ftz and Ftz-F1 form a novel partnership in vivo as a Hox/orphan receptor heterodimer. Here we show that the murine Ftz-F1 ortholog SF-1 functionally substitutes for Ftz-F1 in vivo, rescuing the defects of ftz-f1 mutant...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0163128